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Methylene blue (ProvayBlue) is a medication doctors use to treat a rare blood condition called methemoglobinemia

Although the results could not be replicated by others, 180 15 years later Joseph Weiss 181 was able to achieve significant tumor growth inhibition in 20 out of 90 incurable cancer patients with a similar method

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To achieve comparable effects, oral doses must be 30-50 times higher, creating cost and side effect challenges

The mTOR inhibitor, rapamycin (Rapa), was used to further elucidate VDAC1-mediated modulation of the AMPK/mTOR pathway